Buprenorphine (subutex)8mg


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What is Buprenorphine ?

Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue, in the cheek, by injection, as a skin patch, or as an implant.

SUBUTEX tablets contain the active ingredient buprenorphine hydrochloride. It acts as a substitute for opioids like heroin, morphine, oxycodone or codeine and it helps withdrawal from opioids over a period of time.

Common adverse drugs reactions associated with the use of buprenorphine, similar to those of other opioids, include nausea and vomiting, drowsiness, dizziness, headache, memory loss, cognitive and neural inhibition, perspiration, itchiness, dry mouth, shrinking of the pupils of the eyes (miosis), orthostatic hypotension, male ejaculatory difficulty, decreased libido, and urinary retention.

Constipation and central nervous system (CNS) effects are seen less frequently than with morphine.

subutex is used to treat people with opioid use disorder. In the U.S., the combination formulation of butec patches/naloxone is generally prescribed to deter injection, since naloxone, an opioid antagonist, causes acute withdrawal if the formulation is crushed and injected.

 However, taken orally, the nalaxone has virtually no effect, due to the drug’s extremely high first-pass metabolism and low bioavailability (2%).

Before starting buy  suboxone, individuals are generally advised to wait long enough after their last dose of opioid until they have some withdrawal symptoms to allow for the medication to bind the receptors, since if taken too soon, Buy subutex can displace other opioids bound to the receptors and precipitate an acute withdrawal.

The dose of buprenorphine is then adjusted until symptoms improve, and individuals remain on a maintenance dose of 8–16 mg.

 Because withdrawal is uncomfortable and a deterrent for many patients, many have begun to call for different means of treatment initiation.

Some providers have begun to use the Bernese method, also known as microdosing, in which very small doses of butrans patch are given while patients are still using street opioids, and without precipitating withdrawal, with medicine levels slowly titrated upward.

Buprenorphine versus methadone

Both buprenorphine and methadone are medications used for detoxification and opioid replacement therapy, and appear to have similar effectiveness based on limited data.

Both are safe for pregnant women with opioid use disorder, although preliminary evidence suggests that methadone is more likely to cause neonatal abstinence syndrome.

 In the US and European Union, only designated clinics can prescribe methadone for opioid use disorder, requiring patients to travel to the clinic daily.

If patients are drug free for a period they may be permitted to receive “take home doses,” reducing their visits to as little as once a week.

Alternatively, up to a month’s supply of suboxone online has been able to be prescribed by clinicians in the US or Europe who have completed a basic training (8–24 hours in the US) and received a waiver/licence allowing prescription of the medicine.

 In France, buprenorphine patch prescription for opioid use disorder has been permitted without any special training or restrictions since 1995, resulting in treatment of approximately ten times more patients per year with suboxone than with methadone in the following decade.

 In 2021, seeking to address record levels of opioid overdose, the United States also removed the requirement for a special waiver for prescribing physicians.

Whether this change will be sufficient to impact prescription is unclear, since even before the change as many as half of physicians with a waiver permitting them to prescribe buy Subutex did not do so, and one third of non-waivered physicians reported that nothing would induce them to prescribe suboxone for opioid use disorder.

Chronic pain

A transdermal patch is available for the treatment of chronic pain. These patches are not indicated for use in acute pain, pain that is expected to last only for a short period of time, or pain after surgery, nor are they recommended for opioid addiction.


With respect to equianalgesic dosing, when used sublingually, the potency of buprenorphine is about 40 to 70 times that of morphine. When used as a transdermal patch, the potency of buprenorphine may be 100 to 115 times that of morphine.

Veterinary uses

Veterinarians frequently administer buprenorphine for perioperative pain, particularly in cats, where its effects are similar to morphine.

The drug’s legal status and lower potential for human abuse makes it an attractive alternative to other opioids.

Adverse Effects of subutex.



Common adverse drug reactions associated with the use of buprenorphine, similar to those of other opioids, include nausea and vomiting, drowsiness, dizziness, headache, memory loss, cognitive and neural inhibition, perspiration, itchiness, dry mouth, shrinking of the pupils of the eyes (miosis), orthostatic hypotension, male ejaculatory difficulty, decreased libido, and urinary retention.

Constipation and central nervous system (CNS) effects are seen less frequently than with morphine.

Respiratory effects

The most severe side effect associated with buprenorphine is respiratory depression (insufficient breathing). It occurs more often in those who are also taking benzodiazepines or alcohol, or have underlying lung disease.

The usual reversal agents for opioids, such as naloxone, may be only partially effective, and additional efforts to support breathing may be required.

Respiratory depression may be less than with other opioids, particularly with chronic use. In the setting of acute pain management, though, buprenorphine appears to cause the same rate of respiratory depression as other opioids such as morphine.

Buprenorphine dependence

Buprenorphine treatment carries the risk of causing psychological or physiological (physical) dependencies. It has a slow onset of activity, with a long duration of action, and a long half-life of 24 to 60 hours.

Once a patient has stabilised on the (buprenorphine) medication and programme, three options remain – continual use (buprenorphine-only medication), switching to a buprenorphine/naloxone combination, or a medically supervised withdrawal.

Pain management

Achieving acute opioid analgesia is difficult in persons using buprenorphine for pain management.

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