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Pregablin 300mg (Pregabalin)

£70.00£350.00

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What is Pregabalin?

Pregabalin 300mg, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal and generalized anxiety disorder. Pregabalin also has antiallodynic properties

Common side effects include headache, dizziness, sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problems with vision, and weight gain.

Serious side effects may include angioedema, drug misuse, and an increased suicide risk. When prescribed  pregabalin is taken at high doses over a long period of time, addiction may occur, but if taken at usual doses the risk is low. Use during pregnancy or breastfeeding is of unclear safety.

Pregabalin sale was approved for medical use in the United States in 2004. It was developed as a successor to the related gabapentin.

It is available as a generic medication in a number of countries, including the United States as of 2019. A generic version of the extended-release formulation is available in the United States as of April 2021.

In 2020, it was the 78th most commonly prescribed medication in the United States, with more than 9 million prescriptions.

 In the US, Lyrica online is a Schedule V controlled substance under the Controlled Substances Act of 1970. It is a Class C controlled substance in the UK.

Pregabalin uses.

a. Seizures

For drug-resistant focal epilepsy, pregabalin is useful as an add-on therapy to other treatments. Its use alone is less effective than some other seizure medications. It is unclear how it compares to gabapentin for this use.

b. Neuropathic pain

The European Federation of Neurological Societies recommends Lyrica as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.

A minority obtain substantial benefit, and a larger number obtain moderate benefit. It is given equal weight as gabapentin and tricyclic antidepressants as a first line agent, however the latter are less expensive as of 2010.

Lyrica use is as effective at relieving pain as duloxetine and amitriptyline. Combination treatment of Lyrica 300 mg and amitriptyline or duloxetine offers additional pain relief for people whose pain is not adequately controlled with one medication, and is safe.

Studies have shown that higher doses of pregabalin are associated with greater efficacy.

Pregabalin’s use in cancer-associated neuropathic pain is controversial, though such use is common. It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.

Pregabalin is generally not regarded as efficacious in the treatment of acute pain. In trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed.

But people did require less morphine and had fewer opioid-related side effects.  Several possible mechanisms for pain improvement have been discussed.

c. Anxiety disorders

Other uses of Lyrica

Although pregabalin is sometimes prescribed for people with bipolar disorder there is no evidence showing that it is effective.

There is no evidence and significant risk in using pregabalin for sciatica and low back pain. Evidence of benefit in alcohol withdrawal as well as withdrawal from certain other drugs is limited as of 2016.

One study concluded that Lyrica may be a useful prophylactic medication for migraines.

Pregabalin
Migraine headache symptoms

 

Pregabalinonline  is moderately effective and is safe for treatment of generalized anxiety disorder. It is also effective for the short- and long-term treatment of social anxiety disorder and in reducing preoperative anxiety.

 However there is concern regarding pregabalin’s off-label use due to the lack of strong scientific evidence for its efficacy in multiple conditions and its proven side effects.

What to know About pregabalin Use.

Pregabalin is used to treat epilepsy and anxiety. It’s also taken to treat nerve pain. Nerve pain can be caused by different conditions including diabetes and shingles , or an injury. Pregabalin works in different ways:

  • in epilepsy it stops seizures by reducing the abnormal electrical activity in the brain
  • with nerve pain it blocks pain by affecting the pain messages travelling through the brain and down the spine
  • in anxiety it stops your brain from releasing the chemicals that make you feel anxious

  Key facts about Lyrica.

  • You’ll usually take Lyrica for sale in UK 2 or 3 times a day. You can take it with or without food.
  • Lyrica 300mg is often used for epilepsy, but you can also take it to help with pain or anxiety if you do not have epilepsy.

 

  • It takes at least a few weeks for Lyrica to work.
  • The side effects of Lyrica are usually mild and go away by themselves. The most common ones are feeling sleepy, dizziness and headaches.
  • If you have epilepsy it’s important to take pregabalin regularly. Missing doses could trigger a seizure.

Who can and cannot take Lyrica (Pregabalin)

Buy Lyrica is only suitable for adults. It might not be suitable for people older than 65. Do not give it to children under 18.

Cheap Lyrica online is not suitable for some people. To make sure it’s safe for you, tell your doctor if you:

  • have ever had an allergic reaction to pregabalin or any other medicine
  • have ever abused or been addicted to a medicine
  • are trying to get pregnant, already pregnant or breastfeeding
  • are on a controlled sodium diet, or your kidneys do not work well – some brands of pregabalin liquid contain sodium, so speak to your pharmacist or doctor before taking it
  • have any problems that affect your breathing

Lyrica  is a prescription medicine. It’s important to take it as instructed by your doctor.

    Dosage

     The usual dose of Lyrica in UK is between 150mg and 600mg a day, split into 2 or 3 separate doses.

Adverse Effects of Lyrica

Exposure to Lyrica is associated with weight gain, sleepiness and fatigue, dizziness, vertigo, leg swelling, disturbed vision, loss of coordination, and euphoria.

 It has an adverse effect profile similar to other central nervous system depressants. Even though pregabalin is a depressant and anti-convulsant it can sometimes paradoxically induce seizures, particularly in large overdoses. Adverse drug reactions associated with the use of Lyrica include:

  • Very common (10% of people with Lyrica): dizziness, drowsiness.

 

  • Common (1–10% of people with pregabalin): blurred vision, diplopia, increased appetite and subsequent weight gain, euphoria, confusion, vivid dreams, changes in libido (increase or decrease), irritability, ataxia, attention changes, feeling high, abnormal coordination, memory impairment.
  • Infrequent (0.1–1% of people with pregabalin): depression, lethargy, agitation, anorgasmia, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, hypoglycaemia, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, kidney calculus.

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